SHLP6: a novel NLRP3 and Cav1 modulating agent in Cu-induced oxidative stress and neurodegeneration

SHLP-6 upregulated TNF-α (2.16-fold), NLRP3 (1.78-fold), and COX-2 (0.705-fold), while increasing IL-10 (1.84-fold), suggesting neuroinflammation modulation. Antioxidant gene expression (SOD, CAT, GST, and GSH) was significantly upregulated. These findings indicate SHLP-6's potential as a neuroprotective and antioxidant agent against copper sulfate-induced toxicity.