Exclusion of intracranial lesions in mild traumatic brain injury using glial fibrillary acidic protein and ubiquitin C-terminal hydrolase-L1: a European multicenter study
The mTBI assay yielded high sensitivity and NPV for the exclusion of significant intracranial injuries in mTBI patients presenting to the ED within 12 h from injury, performing better than individual biomarkers. A significant age-dependent influence on the predictive performances of the individual biomarkers and the mTBI assay was demonstrated.
Authors
- Mate Lerga
- Marcin Bałuch
- Vesna Šupak Smolčić (ORCID: https://orcid.org/0000-0002-0539-6513)
- Minodora Dobreanu (ORCID: https://orcid.org/0000-0003-3214-3631)
- Dušan Dobrota (ORCID: https://orcid.org/0000-0003-4330-9529)
- Ewelina Stępniewska
- Oana Roxana Oprea (ORCID: https://orcid.org/0000-0002-7435-3525)
- Rakesh Jalali (ORCID: https://orcid.org/0000-0002-2898-9434)
- Egon Kurča (ORCID: https://orcid.org/0000-0002-1025-6830)
- Mariusz Siemiński (ORCID: https://orcid.org/0000-0001-8219-2912)
- Evgenija Homšak (ORCID: https://orcid.org/0000-0003-3904-1814)
- Daniel Čierný (ORCID: https://orcid.org/0000-0002-7880-4194)
- Gregor Prosen (ORCID: https://orcid.org/0000-0002-8901-3064)
- Joanna Malinowska (ORCID: https://orcid.org/0000-0002-5075-974X)
- Martina Martiníková
- Lara Milevoj Kopčinović (ORCID: https://orcid.org/0000-0003-0360-9148)
- Ana Tancabel Mačinković
- Nora Nikolac (ORCID: https://orcid.org/0000-0001-6831-6309)
- Jakub Nożewski (ORCID: https://orcid.org/0000-0002-8765-233X)
- Barbara Mroczko (ORCID: https://orcid.org/0000-0002-4075-8479)
- Ivana Lapić (ORCID: https://orcid.org/0000-0002-0854-4526)
- Matej Strnad
- Marzena Wojewódzka‐Żeleźniakowicz (ORCID: https://orcid.org/0000-0001-8605-455X)
- Štefan Sivák (ORCID: https://orcid.org/0000-0002-0348-3082)
- Lidija Bilić-Zulle (ORCID: https://orcid.org/0000-0002-4497-6457)
- Dunja Rogić (ORCID: https://orcid.org/0000-0001-7097-276X)
- Helena Silva (ORCID: https://orcid.org/0000-0001-8060-2842)
- Małgorzata Dąbrowska (ORCID: https://orcid.org/0000-0001-6212-6715)
- Martina Pavletić
Institutions
- University Hospital Centre Zagreb (HR)
- Medical University of Białystok (PL)
- University of Rijeka (HR)
- University of Zagreb (HR)
- Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș (RO)
- University of Maribor (SI)
- University of Bydgoszcz (PL)
- Catholic University of Croatia (HR)
- Roosevelt Hospital (GT)
- University of Computer Sciences and Economics in Olsztyn (PL)
- Akadémia Umení v Banskej Bystrici (SK)
- Sisters of Charity Hospital (HR)
- University Clinical Centre Maribor (SI)
- University Clinical Centre (PL)
- University of Warmia and Mazury in Olsztyn (PL)
- Comenius University Bratislava (SK)
- Gdańsk Medical University (PL)
Publication Details
- Journal
- European Journal of Emergency Medicine
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1097/mej.0000000000001234
- Citations
- 2
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 2.78