K <sub>2</sub> CO <sub>3</sub> /TFAA-activated diarylation of α-sulfonyl <i>o</i> -hydroxyacetophenones with <i>o</i> -nitroaryl disulfides to construct sulfonyl bis- <i>o</i> -nitroaryl acetophenones
A concise K<sub>2</sub>CO<sub>3</sub>/TFAA-mediated diarylation of readily accessible sulfonyl <i>o</i>-hydroxyacetophenones with <i>o</i>-nitroaryl disulfides is described. This single-step strategy provides a variety of functionalized sulfonyl <i>C</i>- and <i>O</i>-bis-<i>o</i>-nitroaryl acetophenones <i>via</i> the formation of one carbon-carbon single bond and one carbon-oxygen single bond. A plausible mechanism is proposed and discussed. The molecular structures of key products were determined by X-ray analysis.
Authors
- Nai‐Chen Hsueh
- Meng‐Yang Chang (ORCID: https://orcid.org/0000-0002-1983-8570)
Institutions
- Kaohsiung Medical University (TW)
- National Pingtung University of Science and Technology (TW)
- Kaohsiung Medical University Chung-Ho Memorial Hospital (TW)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob00380f
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00