Analysis of Vβ-Segment Diversity of T-Cell Receptor in Residents of the Techa Riverside Villages Chronically Exposed to Radiation in the Long-Term Period
The study revealed a statistically significant increase in the number of Vβ3 and Vβ5.2 T-cell receptor segments in exposed individuals relative to the comparison group (p = 0.03 and p = 0.003, respectively). It was also shown that the distribution of the Vβ-segments of the T-cell receptor is uneven in both study groups. However, there was no significant difference between the repertoires of the T-cell receptor of the studied groups in the Gini-TCR index (p = 0.14).
Authors
- А. V. Akleyev (ORCID: https://orcid.org/0000-0003-2583-5808)
- А. И. Котикова (ORCID: https://orcid.org/0000-0002-1695-1340)
- Е. А. Блинова (ORCID: https://orcid.org/0000-0002-2567-7945)
Institutions
- Chelyabinsk State University (RU)
- Urals Research Center for Radiation Medicine (RU)
Publication Details
- Journal
- Doklady Biochemistry and Biophysics
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1134/s1607672925700048
- Primary Topic
- Carcinogens and Genotoxicity Assessment
- Type
- article
- Field-Weighted Citation Impact
- 0.00