Analysis of Vβ-Segment Diversity of T-Cell Receptor in Residents of the Techa Riverside Villages Chronically Exposed to Radiation in the Long-Term Period

The study revealed a statistically significant increase in the number of Vβ3 and Vβ5.2 T-cell receptor segments in exposed individuals relative to the comparison group (p = 0.03 and p = 0.003, respectively). It was also shown that the distribution of the Vβ-segments of the T-cell receptor is uneven in both study groups. However, there was no significant difference between the repertoires of the T-cell receptor of the studied groups in the Gini-TCR index (p = 0.14).

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Publication Details

Journal
Doklady Biochemistry and Biophysics
Published
2025-04-01
DOI
https://doi.org/10.1134/s1607672925700048
Primary Topic
Carcinogens and Genotoxicity Assessment
Type
article
Field-Weighted Citation Impact
0.00
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article

Analysis of Vβ-Segment Diversity of T-Cell Receptor in Residents of the Techa Riverside Villages Chronically Exposed to Radiation in the Long-Term Period

А. V. Akleyev, А. И. Котикова, Е. А. Блинова
Doklady Biochemistry and Biophysics
Carcinogens and Genotoxicity Assessment
article

Analysis of Vβ-Segment Diversity of T-Cell Receptor in Residents of the Techa Riverside Villages Chronically Exposed to Radiation in the Long-Term Period

А. V. Akleyev, А. И. Котикова, Е. А. Блинова
article en

Abstract

The study revealed a statistically significant increase in the number of Vβ3 and Vβ5.2 T-cell receptor segments in exposed individuals relative to the comparison group (p = 0.03 and p = 0.003, respectively). It was also shown that the distribution of the Vβ-segments of the T-cell receptor is uneven in both study groups. However, there was no significant difference between the repertoires of the T-cell receptor of the studied groups in the Gini-TCR index (p = 0.14).

Doklady Biochemistry and BiophysicsVol. 521(1)
Chelyabinsk State University (RU), Urals Research Center for Radiation Medicine (RU)
Openalex Percentile: Top 92%
Carcinogens and Genotoxicity Assessment
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