Effect of Repair Gene Polymorphism on the Risk of Malignant Neoplasm Development after Chronic Radiation Exposure

Single-stranded DNA break repair gene (XRCC1) rs25487 polymorphism in accordance with the dominant model is associated with an increased risk of MN development in the combined group of the examined persons (OR = 1.79 (1.12‒2.87), p = 0.01) and in the Slavs group (OR = 2.26; 95% CI 1.06-4.81; p = 0.03). The rs861539 polymorphism of the gene involved in homologous recombination (XRCC3) in accordance with the recessive model is associated with a reduced risk of MN development both in the combined group of exposed persons (OR = 0.25 (0.15‒0.41); p < 0.00001) and separately in the group of the Slavs (OR = 0.28 (0.13‒0.60); p < 0.0001) and in the group of the Turkic people (OR = 0.22 (0.11‒0.44); p < 0.0001). The model of interfactorial interactions allowed us to establish a protective effect with respect to the risk of MN development in the carriers of polymorphic loci rs861539 of the XRCC3 gene and rs1130409 of the APEX1 gene (p < 0.001).