Targeted Therapy in Combination with an Agent That Enhances Terminal Differentiation of Cancer Cells

Currently, in addition to standard methods, an approach is being developed for the treatment of oncological diseases in which terminal differentiation of cancer cells is induced by pharmacological drugs, which increases the response to traditional treatment methods. According to literature data, dimethyl sulfoxide (DMSO) is a safe adjuvant that stimulates the differentiation of various types of the cancer cells. A method proposed in the article was designed to eliminate SKOV3.ip1 human ovarian cancer cell adenocarcinomas by combining targeted therapy based on the HER2-specific toxin DARPin-LoPE and treatment with DMSO as an enhancing agent for terminal differentiation of cancer cells.