Well-Differentiated Extraosseous Chondrosarcoma Arising of Gall Bladder: A Detailed Case Report

This article reports a rare case of extraosseous myxoid chondrosarcoma originating from the gallbladder. The patient, a 50-year-old female, presented with recurrent right upper quadrant abdominal pain for over two months, with worsening symptoms in the month prior to admission. Before hospitalization, enhanced computed tomography (CT) of the upper abdomen performed at a local hospital suggested a malignant gallbladder tumor (gallbladder cancer) with lymphadenopathy near the hepatic portal, as well as chronic cholecystitis with gallstones. Upon admission, whole-abdomen enhanced CT and liver-enhanced magnetic resonance imaging (MRI) confirmed uneven thickening of the gallbladder wall and multiple enlarged lymph nodes in the hepatic portal, further supporting the suspicion of gallbladder cancer. Tumor marker tests revealed elevated levels of carbohydrate antigen 19-9 (CA19-9) and cytokeratin 19 fragment. On 12 March 2020, the patient underwent extended radical resection for gallbladder cancer. The procedure included the removal of the gallbladder, hepatic lobe, right half of the colon, and greater omentum, along with extensive lymphadenectomy of the hepatic portal and posterior of the pancreatic head. Postoperative pathological examination confirmed the diagnosis of extraosseous myxoid chondrosarcoma, with the tumor involving the full thickness of the gallbladder, intrahepatic parenchyma, and the serosa to the muscular layer of the intestinal wall. Hematoxylin and eosin staining results supported this diagnosis. The patient recovered well postoperatively and did not receive any additional antitumor therapies, such as chemotherapy or radiotherapy. During a 36-month follow-up period after surgery, no tumor recurrence or metastasis was observed.