scRNA-seq reveals chemotherapy-induced tumor microenvironment changes in pancreatic ductal adenocarcinoma
We described the characteristics of widely expressed markers in different cell types in PDAC. Chemotherapy disrupted the TME balance, altered tumor antigen presentation, and changed <i>PVR</i> signaling. Combining the appropriate chemical and immune therapies could improve the immune therapy response in PDAC.
Authors
- Yuxiong Lu
- Fei Gao (ORCID: https://orcid.org/0000-0003-1987-6961)
- Hua Zhang (ORCID: https://orcid.org/0000-0002-8910-3481)
- Yanyan Zhao (ORCID: https://orcid.org/0000-0002-6940-2206)
Institutions
- National Institutes for Food and Drug Control (CN)
Publication Details
- Journal
- Translational Cancer Research
- Published
- 2025-04-01
- DOI
- https://doi.org/10.21037/tcr-2025-103
- Citations
- 2
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 2.09