Remdesivir associated with reduced mortality in hospitalized COVID-19 patients: treatment effectiveness using real-world data and natural language processing
Using NLP and ML we were able to generate RWE on the effectiveness of RDV in COVID-19 patients, confirming the potential of using this methodology to measure the effectiveness of treatments in pandemics. Our results show that using RDV in hospitalized patients with moderate-to-severe pneumonia is associated with significantly reduced inpatient mortality. Adherence to clinical guideline recommendations has prognostic implications and emerging technologies in identifying eligible patients for treatment and avoiding missed opportunities during public health crises are needed.
Authors
- Laura Portillo Horcajada
- Rosa de Miguel Buckley (ORCID: https://orcid.org/0000-0003-2749-818X)
- Adrián Ferré Beltrán
- Paulo Vitor Carvalho (ORCID: https://orcid.org/0000-0002-9924-3656)
- José Ramón Arribas (ORCID: https://orcid.org/0000-0002-7410-9450)
- Francisco Fanjul (ORCID: https://orcid.org/0000-0003-1852-0330)
- Paola Pérez (ORCID: https://orcid.org/0000-0002-1695-5763)
- Beatriz Díaz‐Pollán (ORCID: https://orcid.org/0000-0002-7241-4208)
- Cristina Pérez (ORCID: https://orcid.org/0000-0003-4957-1499)
- M Seco
Institutions
- Hospital Universitario La Paz (ES)
- Hospital La Paz Institute for Health Research (ES)
- Gilead Sciences (Spain) (ES)
- Health Research Institute of the Balearic Islands (ES)
- Hospital Universitario Son Espases (ES)
- Hospital Universitario Infanta Sofía (ES)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2025-04-12
- DOI
- https://doi.org/10.1186/s12879-025-10817-6
- Citations
- 2
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- Gilead Sciences