Machine Learning Models of Early Longitudinal Toxicity Trajectories Predict Cetuximab Concentration and Metastatic Colorectal Cancer Survival in the Canadian Cancer Trials Group/AGITG CO.17/20 Trials
We used an innovative machine learning approach to analyze longitudinal joint drug toxicities, demonstrating their role in predicting patient outcomes through a putative pharmacokinetic mechanism.
Authors
- Divya Sharma (ORCID: https://orcid.org/0000-0002-1103-3137)
- Maria C. Xu (ORCID: https://orcid.org/0000-0002-7513-4623)
- Kaitlyn Chiasson
- M. Catherine Brown (ORCID: https://orcid.org/0000-0003-0184-7732)
- Katrina Hueniken (ORCID: https://orcid.org/0000-0003-1376-8046)
- Mona Wahba
- Christopher O’Callaghan (ORCID: https://orcid.org/0000-0002-8633-2473)
- Dongsheng Tu (ORCID: https://orcid.org/0000-0003-4842-2184)
- Derek J. Jonker (ORCID: https://orcid.org/0009-0008-1103-3429)
- Danielle Lilly Nicholls (ORCID: https://orcid.org/0000-0002-6530-0130)
- Eric X. Chen (ORCID: https://orcid.org/0000-0002-4581-8848)
- Christos S. Karapetis (ORCID: https://orcid.org/0000-0003-1741-996X)
- Luna Jia Zhan (ORCID: https://orcid.org/0000-0003-2534-7230)
- Robert John Simes (ORCID: https://orcid.org/0000-0002-3740-7563)
- Benjamin Grant (ORCID: https://orcid.org/0000-0002-2664-5830)
- Jeremy Shapiro (ORCID: https://orcid.org/0009-0007-9290-8145)
- Geoffrey Liu (ORCID: https://orcid.org/0000-0002-2603-7296)
Institutions
- The University of Sydney (AU)
- University of Ottawa (CA)
- Flinders University (AU)
- University of Toronto (CA)
- Queen's University (CA)
- Ottawa Hospital (CA)
- Princess Margaret Cancer Centre (CA)
- Flinders Medical Centre (AU)
- Cabrini Hospital (AU)
- Public Health Ontario (CA)
- National Health and Medical Research Council (AU)
- Monash University (AU)
Publication Details
- Journal
- JCO Clinical Cancer Informatics
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1200/cci.24.00114
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00