Machine Learning Models of Early Longitudinal Toxicity Trajectories Predict Cetuximab Concentration and Metastatic Colorectal Cancer Survival in the Canadian Cancer Trials Group/AGITG CO.17/20 Trials

We used an innovative machine learning approach to analyze longitudinal joint drug toxicities, demonstrating their role in predicting patient outcomes through a putative pharmacokinetic mechanism.

Authors

Institutions

Publication Details

Journal
JCO Clinical Cancer Informatics
Published
2025-04-01
DOI
https://doi.org/10.1200/cci.24.00114
Primary Topic
Colorectal Cancer Treatments and Studies
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Machine Learning Models of Early Longitudinal Toxicity Trajectories Predict Cetuximab Concentration and Metastatic Colorectal Cancer Survival in the Canadian Cancer Trials Group/AGITG CO.17/20 Trials

Divya Sharma, Maria C. Xu, Kaitlyn Chiasson, M. Catherine Brown et al.
JCO Clinical Cancer Informatics
Colorectal Cancer Treatments and Studies
article

Machine Learning Models of Early Longitudinal Toxicity Trajectories Predict Cetuximab Concentration and Metastatic Colorectal Cancer Survival in the Canadian Cancer Trials Group/AGITG CO.17/20 Trials

Divya Sharma, Maria C. Xu, Kaitlyn Chiasson, M. Catherine Brown, Katrina Hueniken, Mona Wahba, Christopher O’Callaghan, Dongsheng Tu, Derek J. Jonker, Danielle Lilly Nicholls, Eric X. Chen, Christos S. Karapetis, Luna Jia Zhan, Robert John Simes, Benjamin Grant, Jeremy Shapiro, Geoffrey Liu
article en

Abstract

We used an innovative machine learning approach to analyze longitudinal joint drug toxicities, demonstrating their role in predicting patient outcomes through a putative pharmacokinetic mechanism.

JCO Clinical Cancer InformaticsVol. 9(9)
The University of Sydney (AU), University of Ottawa (CA), Flinders University (AU), University of Toronto (CA), Queen's University (CA), Ottawa Hospital (CA), Princess Margaret Cancer Centre (CA), Flinders Medical Centre (AU), Cabrini Hospital (AU), Public Health Ontario (CA), National Health and Medical Research Council (AU), Monash University (AU)
Good health and well-being
Openalex Percentile: Top 89%
Colorectal Cancer Treatments and Studies
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.