A pilot study evaluating the feasibility of enriching and detecting circulating tumour cells from peripheral and ovarian veins in rare epithelial ovarian carcinomas
Here we demonstrate the feasibility of enriching and detecting CTCs from both peripheral and ovarian vein blood in patients with rare EOC. The higher CTC yield in ovarian vein blood suggests that tumour-draining blood may play a role in improving CTC detection. This pilot study paves the way for larger studies to investigate the prognostic utility of CTCs and refine their clinical value in these rare understudied EOC.
Authors
- Cara Martin (ORCID: https://orcid.org/0000-0001-8411-8564)
- Ezgi Öner (ORCID: https://orcid.org/0000-0002-4684-8221)
- Lucy Norris (ORCID: https://orcid.org/0000-0001-7862-3230)
- Volga M Saini (ORCID: https://orcid.org/0000-0003-2171-4689)
- Kathy Gately (ORCID: https://orcid.org/0000-0002-9616-424X)
- Catherine O’Gorman (ORCID: https://orcid.org/0000-0001-9463-751X)
- Sinéad Hurley
- Lorraine O’Driscoll (ORCID: https://orcid.org/0000-0002-9860-8262)
- Tanya Kelly
- Sharon O’Toole (ORCID: https://orcid.org/0000-0002-9260-3225)
- Mark P. Ward (ORCID: https://orcid.org/0000-0002-9356-7246)
- Elzahra Ibrahim
- John O’Leary (ORCID: https://orcid.org/0000-0001-7311-9326)
- Karen A. Cadoo (ORCID: https://orcid.org/0000-0002-8384-7148)
- Feras Abu Saadeh (ORCID: https://orcid.org/0000-0002-9598-8650)
- James Beirne (ORCID: https://orcid.org/0000-0003-3053-3556)
- Faye Lewis (ORCID: https://orcid.org/0000-0002-3313-0894)
- Marika Kanjuga
- Patrick Maguire (ORCID: https://orcid.org/0000-0002-3634-9074)
- Brian E. Henderson
- Waseem Kamran
Institutions
- Trinity College Dublin (IE)
- Hermitage Museum (US)
- St. James's Hospital (IE)
Publication Details
- Journal
- European Journal of Surgical Oncology
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1016/j.ejso.2025.109721
- Citations
- 4
- Primary Topic
- Ovarian cancer diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 6.79