Biotechnological approaches in cardiology based on modulation of mechanisms involving interleukin-1

Cardiovascular diseases (CVD) are the leading cause of death and disability worldwide. Low-grade chronic inflammation plays a major role in the progression of CVD. The review examines the role of interleukin-1 (IL-1) family cytokines in the development of CVD. IL-1 family cytokines play an important role in the progression of atherosclerosis, the development of myocardial infarction (MI), and chronic heart failure (CHF). The review presents data on the mechanisms of IL-1 action and the effectiveness of anti-IL-1 drugs in the prevention of CVD. Also, in this review, we consider the possibility of using changes in the composition of intestinal microbiota as a method of influencing the level of IL-1.