Myristic acid beneficially modulates intervertebral disc degeneration by preventing endplate osteochondral remodeling and vertebral osteoporosis in naturally aged mice
The findings of this research suggest that MA is capable of inhibiting endplate osteochondral remodeling and vertebral osteoporosis, diminishing osteoclastogenesis to preserve bone mass, and consequently delaying IDD in naturally aged mice. Hence, MA holds the potential to serve as an alternative therapeutic approach for IDD.
Authors
- Zelin Zhou (ORCID: https://orcid.org/0009-0000-3324-3816)
- Yanchi Gan
- Gengyang Shen
- Jiahui He (ORCID: https://orcid.org/0000-0002-7123-5726)
- Weicheng Qin
- Qi Shang (ORCID: https://orcid.org/0000-0001-9135-2666)
- Xingda Chen (ORCID: https://orcid.org/0009-0008-2758-3310)
- Kai Tang (ORCID: https://orcid.org/0000-0001-6897-5857)
- Yang Liu (ORCID: https://orcid.org/0000-0002-9442-700X)
- Yan Gong
- Honglin Chen (ORCID: https://orcid.org/0000-0001-5108-8338)
- Jie Ma (ORCID: https://orcid.org/0000-0002-7570-9554)
- Yuzhuo Zhang (ORCID: https://orcid.org/0000-0003-2380-2922)
- De Liang (ORCID: https://orcid.org/0000-0002-9765-7126)
- Zhaojun Cheng (ORCID: https://orcid.org/0000-0002-3246-0007)
- Xiaobing Jiang (ORCID: https://orcid.org/0000-0002-1121-0770)
- Guifeng Chen
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Shanghai Ninth People's Hospital (CN)
- First Affiliated Hospital of Guangzhou University of Chinese Medicine (CN)
- Guangxi University of Chinese Medicine (CN)
- China Academy of Chinese Medical Sciences (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-01
- DOI
- https://doi.org/10.3389/fphar.2025.1517221
- Citations
- 2
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- National Natural Science Foundation of China
- Guangzhou University of Chinese Medicine
- Guangzhou University