Pharmacogenetics polygenic response score predicts outcomes in aspirin-treated stroke patients
Our findings suggest that rs1045642 and rs1371097 genotypes contribute to variability in aspirin response among AIS patients. The developed PgxRS, incorporating these SNPs and clinical factors, can potentially aid in risk stratification and guide personalized antiplatelet therapy decisions. However, further validation in larger, diverse cohorts is warranted.
Authors
- Zhi-Zhang Li
- Yunhua Yue
- Daizhan Zhou (ORCID: https://orcid.org/0000-0001-9104-2801)
- Dong Zhang (ORCID: https://orcid.org/0000-0001-7002-7661)
- Xiaoguang Zhang (ORCID: https://orcid.org/0000-0003-0092-5006)
- Yang Bai (ORCID: https://orcid.org/0000-0003-2652-7022)
- Jie Xue
- Hu L (ORCID: https://orcid.org/0000-0002-3955-7530)
- Ying Ding (ORCID: https://orcid.org/0000-0002-0172-1091)
- Dan-Zhuoma Ci
Institutions
- Boston College (US)
- Yangpu Hospital of Tongji University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-01
- DOI
- https://doi.org/10.3389/fphar.2025.1519383
- Primary Topic
- Antiplatelet Therapy and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality