Tumor Necrosis Factor-Like Ligand 1A/Death Receptor 3 Signaling Regulates the Generation of Pathogenic T Helper 9 Cells in Experimental Crohn’s Disease
We demonstrate that the functional DR3 receptor is essential for Th9 cell pathogenicity, revealing a new mechanism by which TL1A/DR3 signaling drives experimental CD-like ileitis. The TL1A/DR3/Th9 proinflammatory pathway may offer a novel therapeutic target for patients with CD.
Authors
- Abdullah Ösme (ORCID: https://orcid.org/0000-0002-7854-3668)
- Fabio Cominelli (ORCID: https://orcid.org/0000-0002-1571-1548)
- Ludovica F. Buttó (ORCID: https://orcid.org/0000-0003-0579-2521)
- Adrian Gomez-Nguyen (ORCID: https://orcid.org/0000-0002-7226-6428)
- Hannah L. Wargo (ORCID: https://orcid.org/0000-0001-5748-0832)
- Theresa T. Pizarro (ORCID: https://orcid.org/0000-0003-3163-915X)
- Stefania De Santis (ORCID: https://orcid.org/0000-0001-6877-2208)
- Natalia Aladyshkina
- Paola Menghini (ORCID: https://orcid.org/0000-0002-8779-088X)
- Giorgos Bamias (ORCID: https://orcid.org/0000-0002-5492-5717)
- Ricky Chan
- Kristine-Ann Buela
Institutions
- National and Kapodistrian University of Athens (GR)
- University School (US)
- Sotiria General Hospital (GR)
- Case Western Reserve University (US)
Publication Details
- Journal
- Gastroenterology
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1053/j.gastro.2025.03.035
- Citations
- 6
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 4.78
Funders
- Foundation for the National Institutes of Health
- Case Western Reserve University
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases