Depolymerase as a potent adjunct to polymyxin for targeting KL160 pandrug-resistant <i>Acinetobacter baumannii</i> in a murine bacteremia model
This study identifies a KL160-targeting depolymerase and demonstrates its potent synergy with polymyxin B in treating A. baumannii bacteremia, supporting its potential for clinical application.
Authors
- Peng-Cheng Yi
- Liu‐Lin Xiong (ORCID: https://orcid.org/0000-0002-1623-5969)
- Jinhong Yu (ORCID: https://orcid.org/0000-0001-9134-7568)
- Du-Xian Liu
- Weixiao Wang (ORCID: https://orcid.org/0000-0002-0385-017X)
- Bailing Zhang (ORCID: https://orcid.org/0000-0002-5472-2100)
- Hui Li (ORCID: https://orcid.org/0000-0003-2600-4838)
- Yi Xu (ORCID: https://orcid.org/0000-0002-3936-216X)
- Jinghan Gao (ORCID: https://orcid.org/0000-0003-4264-6136)
- Mingyu Jiang (ORCID: https://orcid.org/0000-0003-2059-4937)
- Xiuzhen Chen (ORCID: https://orcid.org/0000-0002-3027-6441)
- Chang‐Qi Ma (ORCID: https://orcid.org/0000-0002-9293-5027)
- Wei Chen (ORCID: https://orcid.org/0000-0003-4412-9060)
- Ying Chen (ORCID: https://orcid.org/0009-0000-4812-7658)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nanchang University (CN)
- Jiangxi Provincial People's Hospital (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- Jiangxi Chest Hospital (CN)
- Nanjing Second Hospital (CN)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1093/jac/dkaf110
- Citations
- 2
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 1.18