Ligand Engagement Induces LAG3 Checkpoint Activity through Ubiquitination

Major Finding: Ligand engagement–induced polyubiquitination activates LAG3 by blocking LAG3 membrane binding.Concept: LAG3 ubiquitination is mediated by Cbl family ligases and is required for LAG3 checkpoint function. Impact: Coexpression of LAG3 and CBL is a potential biomarker for response to LAG3-targeted immunotherapy.

Publication Details

Journal
Cancer Discovery
Published
2025-01-01
DOI
https://doi.org/10.1158/2159-8290.cd-rw2025-038
Primary Topic
Ubiquitin and proteasome pathways
Type
article
Field-Weighted Citation Impact
0.00
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article

Ligand Engagement Induces LAG3 Checkpoint Activity through Ubiquitination

Cancer Discovery
Ubiquitin and proteasome pathways
article

Ligand Engagement Induces LAG3 Checkpoint Activity through Ubiquitination

article en

Abstract

Major Finding: Ligand engagement–induced polyubiquitination activates LAG3 by blocking LAG3 membrane binding.Concept: LAG3 ubiquitination is mediated by Cbl family ligases and is required for LAG3 checkpoint function. Impact: Coexpression of LAG3 and CBL is a potential biomarker for response to LAG3-targeted immunotherapy.

Cancer Discovery
Zero hunger
Openalex Percentile: Top 94%
Ubiquitin and proteasome pathways
DOISourceOpenAlex
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Ligand Engagement Induces LAG3 Checkpoint Activity through Ubiquitination · Cancer Discovery (2025) | TGRS Research Map | TGRS