Beta 2 adrenergic receptor gene methylation activates innate lymphoid cells to drive hypertension in lymphocyte deficient hosts
These findings illustrate that the modulation of NK/ILCs activation by adrenergic signalling governs an escape mechanism in lymphocyte-deficient host, enabling the development of hypertension.
Authors
- Elizabeth M. Hennen (ORCID: https://orcid.org/0000-0002-1823-5751)
- David G. Harrison (ORCID: https://orcid.org/0000-0001-9363-6451)
- Agnese Migliaccio (ORCID: https://orcid.org/0000-0003-0500-6279)
- Francesco Mastroiacovo (ORCID: https://orcid.org/0000-0001-5704-8599)
- Sara Perrotta (ORCID: https://orcid.org/0000-0002-2903-3223)
- Giuseppe Lembo (ORCID: https://orcid.org/0000-0002-3510-223X)
- Liang Xiao
- Giuseppe Sciumè (ORCID: https://orcid.org/0000-0003-0131-512X)
- Mingfang Ao (ORCID: https://orcid.org/0000-0002-3639-8546)
- Lorenzo Carnevale (ORCID: https://orcid.org/0000-0002-6422-8253)
- Wei Chen (ORCID: https://orcid.org/0000-0003-0121-6172)
- Marwa A. Abdel-Dayem
- Stefania Fardella (ORCID: https://orcid.org/0000-0002-1448-2165)
- David M. Patrick (ORCID: https://orcid.org/0000-0002-3412-447X)
- Daniela Carnevale (ORCID: https://orcid.org/0000-0002-5016-3161)
- Fabio Pallante (ORCID: https://orcid.org/0000-0001-9224-6267)
- Shilin Zhao (ORCID: https://orcid.org/0000-0002-3921-3965)
- Azzurra Zonfrilli
- Lan Lan (ORCID: https://orcid.org/0000-0002-4599-1042)
- Luis Miguel Rivera-Medina
Institutions
- Damietta University (EG)
- Istituto Neurologico Mediterraneo (IT)
- First Affiliated Hospital Zhejiang University (CN)
- Sapienza University of Rome (IT)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1093/cvr/cvaf042
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health