Dysbiosis as a Risk Factor for Endometriosis: A Synthesis of Systematic Reviews and Meta-analyses

Introduction: Endometriosis is a chronic inflammation that represents one of the most common benign gynecological diseases. It is a condition in which endometrial-like tissue grows outside the uterine cavity, implanting itself in tissues and organs, causing pelvic pain, dysmenorrhea and infertility. The increase in Escherichia coli and bacterial endotoxins are associated with the proliferation of endometriotic lesions by activating inflammatory factors. In the cervicovaginal microbiome, the dominance of Lactobacillus is associated with gynecological and reproductive health. Objective: To perform a synthesis of systematic reviews and meta-analyses published on the association of dysbiosis with the development of endometriosis . Methodology: Systematic literature search in the PubMed, BVS, Scielo and Cochrane library platforms, using the descriptors Dysbiosis OR “microbiota imbalance” OR “vaginal microbiome” OR “gut microbiota” AND Bacterial Vaginosis OR “bacterial vaginosis” OR “Gardnerella vaginalis” OR “vaginal dysbiosis” AND Endometriosis OR “endometriotic lesions” OR “chronic pelvic pain” OR “ectopic endometrium” and their combinations. Results: A total of 383 productions were found in the searched platforms, after selection stages, two articles were selected, both of which are systematic reviews or meta-analyses that met the eligibility criteria. Conclusion: The association between endometriosis and the presence of dysbiosis in samples collected from the intestine, vagina and peritoneal fluid of patients with endometriosis was shown to be significant.