CD73<sup>low</sup> B-cell phenotypes and distinct cytokine profiles in patients with active anti-Jo-1 antibody positive idiopathic inflammatory myopathies
Since CD73 has an immunoregulatory function by modulating the ATP/adenosine pathway, which is also targeted by methotrexate, the low CD73 B-cell expression in anti-Jo-1 antibody-positive IIM may lead to B-cell hyperactivation. These novel findings further highlight B cells as central in the pathogenesis of IIM and important therapeutic targets.
Authors
- Ingrid E. Lundberg (ORCID: https://orcid.org/0000-0002-6068-9212)
- Karin Lodin (ORCID: https://orcid.org/0000-0002-3789-199X)
- Charlotte de Vries (ORCID: https://orcid.org/0000-0001-8955-0479)
- Begum Horuluoglu (ORCID: https://orcid.org/0000-0003-2241-5170)
- Caroline Grönwall (ORCID: https://orcid.org/0000-0002-9111-5537)
- M. Nakazawa (ORCID: https://orcid.org/0000-0001-7973-5373)
- Vivianne Malmström (ORCID: https://orcid.org/0000-0001-9251-8082)
Institutions
- Karolinska University Hospital (SE)
- Keio University (JP)
- Japan Society for the Promotion of Science (JP)
Publication Details
- Journal
- RMD Open
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1136/rmdopen-2024-005401
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Vetenskapsrådet
- Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse
- Reumatikerförbundet