Integration of transcriptome and immunophenotyping data highlights differences in the pathogenetic kinetics of B cells across immune-mediated disease
Immunophenotyping-based clusters and transcriptome-based states revealed quantitative and qualitative differences in B cells. To predict IMD prognosis, assessing both the quantity and quality of naïve B cells may be crucial.
Authors
- Toshihiko Komai (ORCID: https://orcid.org/0000-0001-5890-3606)
- Hirofumi Shoda (ORCID: https://orcid.org/0000-0002-1536-0303)
- Tomohisa Okamura (ORCID: https://orcid.org/0000-0001-7257-5557)
- Yasuo Nagafuchi (ORCID: https://orcid.org/0000-0002-1316-8035)
- Kosuke Matsuki
- Shinji Izuka (ORCID: https://orcid.org/0000-0002-9724-4911)
- Takahiro Itamiya (ORCID: https://orcid.org/0000-0002-1020-0108)
- Saeko Yamada (ORCID: https://orcid.org/0000-0001-8561-4463)
- Keishi Fujio (ORCID: https://orcid.org/0000-0001-7276-5254)
- Kazuhiko Yamamoto (ORCID: https://orcid.org/0000-0001-9037-3625)
- Mineto Ota (ORCID: https://orcid.org/0000-0003-4552-8573)
Institutions
- RIKEN Center for Integrative Medical Sciences (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- RMD Open
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1136/rmdopen-2024-005310
- Citations
- 1
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Japan Agency for Medical Research and Development
- Japan Science and Technology Agency