Store-operated Ca <sup>2+</sup> entry contributes to the ASM phenotype transition in asthma

These findings underscored the significant role of STIM1/Orai1-mediated SOCE in ASMC phenotype modulation and its impact on the excessive ECM deposition driven by ASMCs. Thus, our findings suggest that STIM1/Orai1-mediated SOCE may contribute to airway remodeling in asthma.

Authors

Hangqi Ni
Mengling Xia (ORCID: https://orcid.org/0000-0002-5371-1565)
Ting Li (ORCID: https://orcid.org/0000-0002-8503-5856)
Wang Qing (ORCID: https://orcid.org/0000-0001-9774-1996)
Junjun Chen (ORCID: https://orcid.org/0000-0001-7968-7471)
Yuying Wei (ORCID: https://orcid.org/0009-0000-5581-4747)

Institutions

First Affiliated Hospital Zhejiang University (CN)

Publication Details

Journal: Experimental Lung Research
Published: 2025-04-09
DOI: https://doi.org/10.1080/01902148.2025.2486951
Citations: 1
Primary Topic: Ion channel regulation and function
Type: article
Field-Weighted Citation Impact: 0.81

Funders

National Natural Science Foundation of China

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article

Store-operated Ca ²⁺ entry contributes to the ASM phenotype transition in asthma

Hangqi Ni, Mengling Xia, Ting Li, Wang Qing et al.

Apr 9, 2025

1 citations

Experimental Lung Research

Ion channel regulation and function

0.81

article

Store-operated Ca ²⁺ entry contributes to the ASM phenotype transition in asthma

Hangqi Ni, Mengling Xia, Ting Li, Wang Qing, Junjun Chen, Yuying Wei

April 9, 2025article en

1 citations

Abstract

These findings underscored the significant role of STIM1/Orai1-mediated SOCE in ASMC phenotype modulation and its impact on the excessive ECM deposition driven by ASMCs. Thus, our findings suggest that STIM1/Orai1-mediated SOCE may contribute to airway remodeling in asthma.

Experimental Lung ResearchVol. 51(1)

First Affiliated Hospital Zhejiang University (CN)

National Natural Science Foundation of China

Zero hunger

Openalex Percentile: Top 29%

Ion channel regulation and function

0.81

DOI Open Access PDF OpenAlex

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