Neural crest-associated gene FOXD1 induces an immunosuppressive microenvironment by regulating myeloid-derived suppressor cells in melanoma
Our study elucidated a novel function of FOXD1 in melanoma pathogenesis, highlighting its role in orchestrating the immunosuppressive TME by promoting the generation of MDSC via IL6 upregulation.
Authors
- Nina Wang
- Jochen Sven Utikal (ORCID: https://orcid.org/0000-0001-5316-0241)
- Lidong Gong (ORCID: https://orcid.org/0000-0001-9575-2288)
- Juliane Poelchen
- Feyza Gül Özbay Kurt (ORCID: https://orcid.org/0000-0003-4086-6469)
- Yiman Wang (ORCID: https://orcid.org/0000-0002-0629-2169)
- Shibo Liu (ORCID: https://orcid.org/0000-0001-8623-9028)
- Kilian Wistuba‐Hamprecht (ORCID: https://orcid.org/0000-0002-3104-8512)
- Rebekka Bitsch (ORCID: https://orcid.org/0000-0002-1065-656X)
- Viktor Umansky (ORCID: https://orcid.org/0000-0003-0259-1839)
- Yuxin Zhang (ORCID: https://orcid.org/0000-0001-7224-2533)
- Huizi Wu
- Rui Han
- Sandra Pardo
- Martine Peter
- Qian Sun (ORCID: https://orcid.org/0000-0002-4336-7641)
- Daniel Novak
Institutions
- University of Mannheim (DE)
- German Cancer Research Center (DE)
- Peking University (CN)
- Heidelberg University (DE)
- Tsinghua University (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1136/jitc-2024-010352
- Citations
- 3
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- Deutsche Forschungsgemeinschaft