Within‐week associations between alcohol and other substance use and interaction with naltrexone among sexual and gender minority men in San Francisco, California, USA

Among adult sexual and gender minority men enrolled in a clinical trial, alcohol use was positively associated with cannabis and cocaine use. Naltrexone may mitigate cocaine use in this group by moderating binge drinking or diminishing the rewarding effects of cocaethylene. Findings highlight the potential of targeted naltrexone as an intervention to address alcohol and cocaine co-use and improve treatment outcomes in this underserved group.