What do we know about neurotoxicity?

Neurologic symptoms caused by drug antitumor therapy remain a problem. The severity and frequency of development of this type of complications depend on the drug group, dose, and duration of use. Effective treatment requires a proper approach to the diagnosis and treatment of toxic reactions. Therapy of neurologic complications during antitumor drug therapy should be based on personalized approach due to the difference in mechanisms of development and degree of toxicity for each drug and particular patient.Literature data on the main groups of neurotoxic drugs, mechanisms of their action and treatment of neurological complications during their administration are reviewed.