The Effect of Some Immunological Markers (IgM, IgG, CCP, IL1) Associated with RA in a Sample of Iraqi Patients

This work was performed on Iraqi patients with rheumatoid arthritis. It collected blood samples from 60 patients with RA whose ages range between 21-70 years. The study included more females than males, as the former was 55 by 91.7%, while the latter was 5 at 8.3%. To compare, 28 other blood samples were drawn from healthy control participants who range from 21-60 years, and the males was 5, 17.9%. The females were 23 by 82.1%, as the highest was in the ages 41-60 years and 51.7 and the age group (≤20) years (3.3%) was lowest as the disease among non-smokers(90.0%) is the largest in comparison to the rate among smokers (10.0%) with significant differences (P<0.001). The disease among married couples (80.0%) was statistically different (P<0.01) as the largest in reference to the unmarried and (20.0%). A significant rise (P<0.001) in Intreleukin- 1 alpha in patients 2.87 units/ml appeared while in healthy people 1.36 units/ml, and a significant rise "(P<0.001) in cyclic citrullinated peptides antibody in the blood of patients relative to the healthy". Here, the protein in the patients' blood was 406.62 mg/L and the 66.07 mg/L in the healthy. A high significant rise (P<0.001) was seen in immunoglobulin IgG in patients rising to 3.39 (ug/ml) and the healthy 0.72 (ug/ml). A significant rise happened (P<0.001) in the immunoglobulin IgM in patients reaching 8.75 (ug/ml).) compared to the healthy at 5.32 (ug/ml). Highlights: Demographics: RA affects mostly females (91.7%), non-smokers (90%), and married (80%). Biomarkers: Significant increases in IL-1α, CCP antibody, IgG, and IgM in RA. Controls: Healthy controls show lower biomarker levels compared to RA patients. Keywords: Marker, IgM, IgG, CCP, IL1.