Hereditary diseases and tumors in children

In recent years, our ability to use genome-wide analyses, including whole-genome and whole-exome sequencing, to determine the genetic basis of pediatric tumors has expanded significantly. In particular, exome sequencing has contributed the evidence that approximately 10 % of children and adolescents with tumors have genetic variant mutations associated with cancer susceptibility.In this review, we present a list of some genetic variations predisposing children to solid tumors.