Metabolism and Excretion of 8-O-Acetylharpagide in Rats and Identification of Its Potential Anti-Breast Cancer Active Metabolites

As a prodrug, 8-O-acetylharpagide is metabolized to M5, which may subsequently exert an anti-breast cancer effect through downregulation of the AKT/NF-κB/MMP9 signaling axis. This study provides a theoretical basis for the clinical application of <i>Ajuga decumbens</i> in breast cancer therapy.

Authors

Binyu Wen (ORCID: https://orcid.org/0000-0002-7549-1508)
Junfeng Gao
Sijia Su (ORCID: https://orcid.org/0009-0001-5682-3175)
Xinyu Zhao (ORCID: https://orcid.org/0000-0002-3607-9000)
Xu Tang (ORCID: https://orcid.org/0000-0002-9096-2961)
Jingna Zhou (ORCID: https://orcid.org/0000-0003-0839-6452)

Institutions

Beijing University of Chinese Medicine (CN)

Publication Details

Journal: Drug Design Development and Therapy
Published: 2025-04-01
DOI: https://doi.org/10.2147/dddt.s487898
Primary Topic: Eicosanoids and Hypertension Pharmacology
Type: article
Field-Weighted Citation Impact: 0.00

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article

Metabolism and Excretion of 8-O-Acetylharpagide in Rats and Identification of Its Potential Anti-Breast Cancer Active Metabolites

Binyu Wen, Junfeng Gao, Sijia Su, Xinyu Zhao et al.

Apr 1, 2025

Drug Design Development and Therapy

Eicosanoids and Hypertension Pharmacology

article

Metabolism and Excretion of 8-O-Acetylharpagide in Rats and Identification of Its Potential Anti-Breast Cancer Active Metabolites

Binyu Wen, Junfeng Gao, Sijia Su, Xinyu Zhao, Xu Tang, Jingna Zhou

April 1, 2025article en

Abstract

As a prodrug, 8-O-acetylharpagide is metabolized to M5, which may subsequently exert an anti-breast cancer effect through downregulation of the AKT/NF-κB/MMP9 signaling axis. This study provides a theoretical basis for the clinical application of <i>Ajuga decumbens</i> in breast cancer therapy.

Drug Design Development and TherapyVol. Volume 19

Beijing University of Chinese Medicine (CN)

Good health and well-being

Openalex Percentile: Top 92%

Eicosanoids and Hypertension Pharmacology

DOI Open Access PDF OpenAlex

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