Network Pharmacology and Molecular Docking Analysis of Chrysoeriol for Alzheimer’s Disease

Alzheimer’s disease is a brain disorder that slowly destroys memory and thinking skills and eventually the ability to carry out daily tasks. Chrysoeriol is a flavone compound that exhibits neuroprotective, anti-inflammatory, cholinesterase inhibitor and antioxidant properties. The potential targets of Alzheimer’s disease were identified by Network Pharmacology. As a result of the analysis, 35 overlapping targets among 100 potential targets for chrysoeriol and 1255 for Alzheimer’s disease were identified. Among the 35 overlapping targets, the Hub genes are highly enriched in the Biological Process, Cellular Component and Molecular Function were analyzed. Further the Molecular Docking analysis revealed that PTGS2, MMP2 and KDR have good binding affinity. It’s shown that chrysoeriol has promising role in modulating key pathways involved in Alzheimer’s disease pathogenesis, paving the way for further experimental validation and drug development.