High-grade corded and hyalinized endometrioid carcinoma of “no specific molecular profile”: report of two cases
The corded component was absent in the hysterectomy specimen of case #1 and in the vaginal biopsy specimen of case #2. The present cases confirm the clinical and molecular heterogeneity of high-grade CHEC, including a wide age range at presentation, variable prognosis, and variable molecular background. Nonetheless, these cases retain unique features that support their distinction from carcinosarcoma and dedifferentiated carcinoma. We suggest to consider them as a variant of FIGO G3 endometrioid carcinoma. Further studies are necessary in this field.
Authors
- Susanna Ronchi
- Nadine Narducci (ORCID: https://orcid.org/0009-0000-0212-0848)
- Carla Facco
- Stefano La Rosa (ORCID: https://orcid.org/0000-0003-1941-2403)
- Angela Santoro (ORCID: https://orcid.org/0000-0002-6964-5152)
- Francesca Addante
- Damiano Arciuolo (ORCID: https://orcid.org/0000-0002-3927-985X)
- Jvan Casarin (ORCID: https://orcid.org/0000-0001-9519-1097)
- Gian Franco Zannoni (ORCID: https://orcid.org/0000-0002-4473-7560)
- Michele Valente
- Antonio Raffone (ORCID: https://orcid.org/0000-0001-5443-2333)
- Giulia Scaglione (ORCID: https://orcid.org/0000-0002-9060-3854)
- Antonio Travaglino (ORCID: https://orcid.org/0000-0003-4002-1618)
- Nicoletta D’Alessandris (ORCID: https://orcid.org/0000-0002-9580-6343)
- Belen Padial Urtueta
Institutions
- Università Cattolica del Sacro Cuore (IT)
- University of Insubria (IT)
- Agostino Gemelli University Polyclinic (IT)
- Aziende Socio Sanitarie Territoriale dei Sette Laghi
- University of Bologna (IT)
Publication Details
- Journal
- Pathologica
- Published
- 2025-04-01
- DOI
- https://doi.org/10.32074/1591-951x-1096
- Citations
- 1
- Primary Topic
- Ovarian cancer diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.70