EGCG‐enabled Deep Tumor Penetration of Phosphatase and Acidity Dual‐responsive Nanotherapeutics for Combinatory Therapy of Breast Cancer (Small 14/2025)
Breast Cancer In article number 2406245, Weidong Dai, Haipeng Lv, Zhi Lin, and co-workers reveal the mechanism through which EGCG alleviates tumor fibrosis to enable deep penetration of dual-responsive nanotherapeutics. EGCG and the dual-responsive nanodrug achieved synergistic starvation-/chemodynamic-/chemo-therapy to eliminate TNBC cells and prevent lung metastasis.
Authors
- Qunhua Peng
- Haipeng Lv (ORCID: https://orcid.org/0000-0002-4644-4323)
- Junfeng Tan (ORCID: https://orcid.org/0000-0001-6714-0284)
- Weidong Dai (ORCID: https://orcid.org/0000-0002-9593-138X)
- Yin Zhu (ORCID: https://orcid.org/0000-0002-1061-5100)
- Yue Zhang (ORCID: https://orcid.org/0000-0002-1259-020X)
- Jiang Tao Shi (ORCID: https://orcid.org/0000-0002-7905-4858)
- Mengxue Zhou (ORCID: https://orcid.org/0000-0001-6962-555X)
- Li Guo (ORCID: https://orcid.org/0000-0002-1459-1118)
- Zhiwei Huang (ORCID: https://orcid.org/0000-0003-4278-1397)
- Huan Geng (ORCID: https://orcid.org/0000-0002-5713-0645)
- Yanni Zhao (ORCID: https://orcid.org/0009-0003-3049-3504)
- Zhiyuan Lin (ORCID: https://orcid.org/0009-0006-4318-9052)
- Chuang Zhou
- Zhi Chao Lin
- Ying Wang (ORCID: https://orcid.org/0009-0008-3662-2692)
- Haijun Yu (ORCID: https://orcid.org/0000-0002-2472-6354)
Institutions
- Chinese Academy of Sciences (CN)
- Shanghai Institute of Materia Medica (CN)
- Chinese Academy of Agricultural Sciences (CN)
- Tea Research Institute (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Shaanxi University of Science and Technology (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Small
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/smll.202570104
- Citations
- 2
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 1.35