Early increase of the synaptic blood marker β‐synuclein in asymptomatic autosomal dominant Alzheimer's disease
Blood β-synuclein levels were already higher in asymptomatic Alzheimer's disease (AD) mutation carriers. Blood β-synuclein levels were highest in symptomatic AD mutation carriers. Blood β-synuclein levels start to rise 11 years before symptom onset. Rise of β-synuclein precedes axonal degeneration, brain atrophy, and cognitive decline. β-synuclein levels gradually increased with declining cognition.
Authors
- Jee Hoon Roh (ORCID: https://orcid.org/0000-0002-3243-0529)
- Mathias Jucker (ORCID: https://orcid.org/0000-0001-9045-1072)
- Peter R. Schofield (ORCID: https://orcid.org/0000-0003-2967-9662)
- Nick C. Fox (ORCID: https://orcid.org/0000-0002-6660-657X)
- Randall John Bateman (ORCID: https://orcid.org/0000-0002-7729-1702)
- Takeshi Ikeuchi (ORCID: https://orcid.org/0000-0001-8828-8085)
- Francisco Lopera (ORCID: https://orcid.org/0000-0003-3986-1484)
- Yoshiki Niimi (ORCID: https://orcid.org/0000-0002-2556-8167)
- Johannes Levin (ORCID: https://orcid.org/0000-0001-5092-4306)
- Raquel Sánchez‐Valle (ORCID: https://orcid.org/0000-0001-7750-896X)
- Patrick Oeckl (ORCID: https://orcid.org/0000-0002-7652-7023)
- Benjamin Mayer (ORCID: https://orcid.org/0000-0003-1042-9006)
- Gregory Scott Day (ORCID: https://orcid.org/0000-0001-5133-5538)
- Eric McDade (ORCID: https://orcid.org/0000-0002-6764-3866)
- Markus Otto (ORCID: https://orcid.org/0000-0003-4273-4267)
- Laura Ibáñez (ORCID: https://orcid.org/0000-0003-2381-7059)
- Edward D. Huey (ORCID: https://orcid.org/0000-0002-8295-5884)
- Christopher M. Morris (ORCID: https://orcid.org/0000-0002-3749-0993)
- Jorge J. Llibre‐Guerra (ORCID: https://orcid.org/0000-0002-2137-7750)
- Jae‐Hong Lee (ORCID: https://orcid.org/0000-0001-7368-4560)
Institutions
- Ulsan College (KR)
- Universität Ulm (DE)
- Washington University in St. Louis (US)
- Brown University (US)
- Korea University Medical Center (KR)
- German Center for Neurodegenerative Diseases (DE)
- Jacksonville College (US)
- Asan Medical Center (KR)
- LMU Klinikum (DE)
- UNSW Sydney (AU)
- Universidad de Antioquia (CO)
- University of Ulsan (KR)
- Munich Cluster for Systems Neurology (DE)
- Hospital Clínic de Barcelona (ES)
- UK Dementia Research Institute (GB)
- Hertie Institute for Clinical Brain Research (DE)
- Mayo Clinic in Florida (US)
- National Hospital for Neurology and Neurosurgery (GB)
- University Hospital Ulm (DE)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- University College London (GB)
- Martin Luther University Halle-Wittenberg (DE)
- Niigata University (JP)
- Universitat de Barcelona (ES)
- The University of Tokyo (JP)
- University of Tübingen (DE)
- Ludwig-Maximilians-Universität München (DE)
- Neuroscience Research Australia (AU)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/alz.70146
- Citations
- 8
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 9.31
Funders
- Alzheimer's Association
- Japan Agency for Medical Research and Development
- Korea Health Industry Development Institute
- Deutsches Zentrum für Neurodegenerative Erkrankungen
- Ministry of Science and ICT, South Korea
- Fleni
- Instituto de Salud Carlos III
- National Institute on Aging