Graphene Oxide Nanosheets Induce Mitochondrial Toxicity in Human Ovarian Granulosa Cells: Implications for Female Reproductive Health
This study demonstrates that short-term exposure to low-dose GO causes mitochondrial damage in human ovarian granulosa cells, highlighting the need for further research on the safety of GO, particularly regarding its potential effects on reproductive health. However, GO-induced transient mitochondrial damage is highly likely to negatively affect ovarian reserve function, which needs to be further verified in animal models.
Authors
- Xiaolei Wang (ORCID: https://orcid.org/0000-0002-7751-4849)
- Hedong Lu
- Dongmei Ji (ORCID: https://orcid.org/0000-0003-0647-0153)
- Weiwei Zou (ORCID: https://orcid.org/0000-0002-5963-7247)
- Chunya Ye
- Zhiguo Zhang (ORCID: https://orcid.org/0000-0003-3982-9900)
- Yunxia Cao (ORCID: https://orcid.org/0000-0001-9631-0799)
- Min Li (ORCID: https://orcid.org/0009-0001-3963-0478)
Institutions
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2147/ijn.s495259
- Citations
- 9
- Primary Topic
- Graphene and Nanomaterials Applications
- Type
- article
- Field-Weighted Citation Impact
- 6.07