Can prostoglandin analogues increase the risk of cystoid macular edema when used perioperatively in patients with open-angle glaucoma?

Currently, the safety of the use of prostoglandin analogues in the patients with concomitant cataracts and POAG during the perioperative period is a topical issue. Objectives. Based on the findings of optical coherence tomography, to study in a comparative aspect the macular thickness changes in the patients with concomitant cataract and concomitant cataracts and primary open-angle glaucoma, instilled with Taflotan during the perioperative period. Materials and methods. The study included 80 patients (126 eyes). The patients were divided into 4 groups: Group 1, i.e. the control group included the patients without POAG. The patients in the remaining groups received different medications: Group 2 — prostaglandin analogues, 3rd Group — combined drug of β-blocker and carbonic anhydrase inhibitor, and Group 4 — prostaglandin analogues + combined drug of β-blocker and carbonic anhydrase inhibitor. Prior to cataract phacoemulsification, the patients’ maculae were imaged using optical coherence tomography on the 7th day, one month, and three months following the surgery. Obtained results. Results of perioperative use of prostaglandin analogues and combined drug of β-blocker and carbonic anhydrase inhibitor in patients with cataracts combined with POAG 3months after surgery as can be seen from the results 88.2 % of patients in Group 1, 94.6 % in Group 2, 100 % in Group 3, and 90 % in Group 4 (p > 0.05). Conclusions. Taflotan did not increase the risk of Cystoid Macular Edema as compared to the control and comparison groups. Keywords: cataracts, POAG, prostaglandin analogues, combined drug of β-blocker and carbonic anhydrase inhibitor, macular thickness, Cystoid Macular Edema