Research Status of Antiviral Therapy for Chronic Hepatitis B

本文旨在全面阐述慢性乙型肝炎(CHB)抗病毒治疗的研究现状。基于核苷(酸)类似物(NAs)、干扰素(IFN)等经典抗病毒药物的作用机制、临床疗效、安全性及耐药性特征，结合最新循证医学证据，探讨现有治疗方案的优化选择策略及其临床应用价值。同时，介绍新型抗病毒药物的研发进展以及联合治疗方案的优化策略，为慢性乙型肝炎的抗病毒治疗提供综合参考。The purpose of this article is to comprehensively describe the research status of antiviral therapy for chronic hepatitis B. By analyzing the mechanism of action, efficacy, safety and drug resistance of common antiviral drugs such as Nucleoside analogues and interferons, the selection basis and clinical application of current treatment regimens were discussed. At the same time, the research and development progress of new antiviral drugs and the optimization strategy of combination therapy regimens are introduced, so as to provide a comprehensive reference for the antiviral treatment of chronic hepatitis B.