FoxP3-positive T regulatory cells and its effector mechanisms in Crohn’s disease: an immunohistochemical and image morphometric analysis on endoscopic mucosal biopsies
Our findings point to the possibility of a qualitative defect in FoxP3+ Tregs in CD. The functional arms of Tregs in CD need to be elucidated further in larger prospective cohorts to validate our observations and pave the way for future immunotherapy.
Authors
- Amit Kumar Satapathy (ORCID: https://orcid.org/0000-0003-1101-7847)
- Somanath Padhi (ORCID: https://orcid.org/0000-0002-3452-7236)
- Pavithra Ayyanar (ORCID: https://orcid.org/0000-0002-4233-6835)
- Mohammed Shahin (ORCID: https://orcid.org/0000-0001-6571-4934)
- Hemanta Kumar Nayak (ORCID: https://orcid.org/0000-0002-2774-219X)
- Saurav Nayak (ORCID: https://orcid.org/0000-0003-2394-295X)
- Susama Patra
- Shalini Chaudhary (ORCID: https://orcid.org/0009-0009-3669-7149)
- Subash Chandra Samal
- Ajit Sahu
- Tapaskanti Parida
Institutions
- All India Institute of Medical Sciences Bhubaneswar (IN)
- University Gastroenterology (US)
- Pediatrics and Genetics (US)
Publication Details
- Journal
- European Journal of Gastroenterology & Hepatology
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1097/meg.0000000000002971
- Citations
- 1
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.82