Why is electroconvulsive therapy for depression more effective in older age? A causal mediation analysis
A total of 43.1% of the effect of older age on increased ECT response was explained by the mediators. Treatment planning could be improved by preferentially offering ECT to older adults, especially if presenting with psychotic features, greater severity of psychomotor disturbance, and earlier in the episode.
Authors
- Sabine Landau (ORCID: https://orcid.org/0000-0002-3615-8075)
- Kelly McDonagh
- Declan M. McLoughlin (ORCID: https://orcid.org/0000-0003-4574-2799)
- Ana Jelovac (ORCID: https://orcid.org/0000-0002-7653-8531)
- Anna Igoe (ORCID: https://orcid.org/0000-0002-5918-1067)
- Martha Finnegan (ORCID: https://orcid.org/0000-0002-3727-3497)
- Gabriele Gusciute (ORCID: https://orcid.org/0000-0002-6799-8501)
- Cathal McCaffrey
- Emma Whooley (ORCID: https://orcid.org/0009-0007-2545-3662)
- Sarah McDonogh
- Sarah E. Thompson
- Petros Beeley
Institutions
- King's College London (GB)
- Trinity College Dublin (IE)
- St. Patrick's Hospital (IE)
Publication Details
- Journal
- Psychological Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1017/s0033291725000807
- Citations
- 6
- Primary Topic
- Electroconvulsive Therapy Studies
- Type
- article
- Field-Weighted Citation Impact
- 8.83