Protective Role of Coffee in Thioacetamide-induced Nephrotoxicity:A Study in Rats
This work shows that coffee can protect the kidneys against thioacetamide-induced nephrotoxicity in a rat model. It highlights the antioxidant potential of coffee by its ability to restore enzymatic antioxidant activity (SOD and catalase), lower oxidative stress markers (MDA), and enhance renal function measures (urea, creatinine, and uric acid). The study fills a significant gap by demonstrating coffee as a viable natural therapeutic agent for oxidative stressinduced kidney impairment, providing an alternative to conventional treatments with fewer side effects.
Authors
- Syeda Nuzhat Fatima Zaidi (ORCID: https://orcid.org/0000-0002-8023-0863)
- Abdullatif Bin Muhsinah (ORCID: https://orcid.org/0000-0002-9742-3573)
- Abdul Kader Mohiuddin (ORCID: https://orcid.org/0000-0003-1596-9757)
- Anar Gojayev (ORCID: https://orcid.org/0000-0002-2649-5326)
- Afnan Jan
- Ajmal Khan (ORCID: https://orcid.org/0000-0001-7851-6080)
Institutions
- Umm al-Qura University (SA)
- University of Nizwa (OM)
- ADA University (AZ)
- Federal Urdu University (PK)
- King Khalid University (SA)
Publication Details
- Journal
- Current Pharmaceutical Biotechnology
- Published
- 2025-04-09
- DOI
- https://doi.org/10.2174/0113892010356725250329094402
- Primary Topic
- Coffee research and impacts
- Type
- article
- Field-Weighted Citation Impact
- 0.00