S-palmitoylation of c-MET by CK2α-mediated zDHHC15 phosphorylation drives glioblastoma stem cell tumorigenicity
This study establishes the CK2α-zDHHC15-c-MET axis as a pivotal regulatory hub in GSC maintenance and identifies c-MET S-palmitoylation as a novel and promising therapeutic target for the treatment of glioblastoma.
Authors
- Hao Xu (ORCID: https://orcid.org/0000-0001-5827-1821)
- Jiachen Xu (ORCID: https://orcid.org/0000-0003-4565-6364)
- Cen Liu (ORCID: https://orcid.org/0009-0003-6198-8120)
- Yiming Tu (ORCID: https://orcid.org/0000-0002-5870-7717)
- Y.-P. Wang (ORCID: https://orcid.org/0009-0002-0707-6668)
- Tao Fu (ORCID: https://orcid.org/0000-0002-6900-5518)
- Yitao Ding (ORCID: https://orcid.org/0000-0002-6552-0838)
- Jun Yin (ORCID: https://orcid.org/0009-0008-5428-9969)
- Shuai Wang (ORCID: https://orcid.org/0000-0003-4672-3055)
- Wei Wu (ORCID: https://orcid.org/0000-0002-6556-067X)
- Wei Dong (ORCID: https://orcid.org/0000-0002-8107-3900)
- Jing Ji (ORCID: https://orcid.org/0000-0002-4269-3250)
- Rui Li (ORCID: https://orcid.org/0000-0001-8353-6772)
- Zhengxin Chen (ORCID: https://orcid.org/0009-0004-1234-7404)
- Huibo Wang (ORCID: https://orcid.org/0000-0001-8062-4873)
- Hui Luo (ORCID: https://orcid.org/0000-0003-2527-0237)
- Mingbo Ding (ORCID: https://orcid.org/0000-0002-8908-337X)
- Minghui Meng
Institutions
- Jiangsu Cancer Hospital (CN)
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1093/neuonc/noaf098
- Citations
- 3
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.81