Remote radical alkynylation of unactivated C(sp<sup>3</sup>)–H bonds of ethynesulfonamides
We report an efficient protocol for the construction of δ-alkynyl amides <i>via</i> 1,5-hydrogen atom transfer and alkynyl group transfer of ethynesulfonamides. The readily installed ethynesulfonamides serve as both an amidyl radical precursor and an alkyne source. This reaction features excellent site selectivity for tertiary, secondary, primary, and benzylic C(sp<sup>3</sup>)-H bonds.
Authors
- Danyang Xie (ORCID: https://orcid.org/0000-0002-7839-9248)
- Mao-Jun Guo (ORCID: https://orcid.org/0009-0001-9804-8082)
- Yong Xia (ORCID: https://orcid.org/0000-0002-9091-5372)
- Bo Qin (ORCID: https://orcid.org/0000-0002-4573-0408)
- Pan Zhou (ORCID: https://orcid.org/0000-0002-8629-4622)
- Li Xu (ORCID: https://orcid.org/0000-0001-6360-8687)
- Jiawei Li
Institutions
- Chongqing University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc01215e
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00