Metabolomic Reprogramming Induced by Benzo[a]pyene in Skin Keratinocytes and Protective Effects of Glutathione Amino Acid Precursors
In summary, GAP shows in vitro protective effects against BaP by maintaining GSH homeostasis, helping metabolic detoxification, reducing DNA damage, and is effective in preventing hyperpigmentation of skin models under pollution challenge.
Authors
- Yiying Dong
- Guoqiang Chen (ORCID: https://orcid.org/0000-0002-6398-740X)
- Tingyan Mi
- Xue Xiao (ORCID: https://orcid.org/0000-0003-1666-3813)
- Hong Zhang (ORCID: https://orcid.org/0000-0002-6191-0046)
- Xiao Cui (ORCID: https://orcid.org/0000-0002-0311-2695)
- Xuelan Gu
Institutions
- Unilever (China) (CN)
Publication Details
- Journal
- Journal of Cosmetic Dermatology
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1111/jocd.70168
- Citations
- 1
- Primary Topic
- Skin Protection and Aging
- Type
- article
- Field-Weighted Citation Impact
- 2.00
Funders
- Chinese Academy of Sciences
- Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences