Improved stereocontrol in reductive aminases through steric modification of residues around substrate and cofactor binding pockets
Multiple residues have been identified at the cofactor and substrate binding pockets in a reductive aminase that can be exploited for stereocontrol through steric modification of their side chains.
Authors
- Ruth T. Bradshaw Allen (ORCID: https://orcid.org/0000-0002-1819-9842)
- Mario Prejanò (ORCID: https://orcid.org/0000-0002-9140-6246)
- Godwin A. Aleku (ORCID: https://orcid.org/0000-0003-0969-5526)
- Z.‐M. XIE
- Jake Gooderham
- David D. Aleku
- Julie Vignot
- Beatrice-Maria Zabavaa
Institutions
- King's College London (GB)
- University of Calabria (IT)
Publication Details
- Journal
- Catalysis Science & Technology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cy00308c
- Citations
- 2
- Primary Topic
- Chemical Synthesis and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Leverhulme Trust
- King's College London
- Università della Calabria