Ascorbic Acid and Esketamine for Mental Disorders in Women with Miscarriage: A Randomized Controlled Double-Blind Trial Protocol
This study provides the clinical trial-based evidence of the effects of AA alone or in combination/interacting with the emerging rapid-acting antidepressant esketamine on depression and other mental disorders in patients with miscarriage undergoing painless curettage. Our data are expected to suggest AA's potential application for optimizing strategies of promoting post-miscarriage mental health, and its possible adjunctive improvement of (es)ketamine's usage as antidepressants. One major limitation is that this study is a single-center study, and the results might be biased due to regional factors.
Authors
- Baihang Cai
- Jie Luo (ORCID: https://orcid.org/0000-0002-0791-1419)
- Yao Ma (ORCID: https://orcid.org/0000-0003-0393-5269)
- Qibin Chen (ORCID: https://orcid.org/0000-0001-5923-8345)
- Ying Zhang
- Z. J. Ke (ORCID: https://orcid.org/0009-0004-5287-7477)
- Linya Deng
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Neuropsychiatric Disease and Treatment
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2147/ndt.s516355
- Citations
- 1
- Primary Topic
- Maternal Mental Health During Pregnancy and Postpartum
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- Natural Science Foundation of Chongqing
- Centre Scientifique et Technique du Bâtiment