Mechanisms underlying the wound healing and tissue regeneration properties of a novel gauze dressing impregnated with traditional herbal medicine (Ya-Samarn-Phlae) in type 2 diabetic Goto-Kakizaki (GK) rats
A gauze dressing impregnated with YaSP provides a practical solution for diabetic wound management and demonstrates strong wound-healing properties by modulating excess inflammation, promoting angiogenesis during the proliferation phase, and regulating collagen synthesis throughout the remodeling phase. This discovery reveals, for the first time, the underlying mechanisms of action of this traditional formulation, highlighting its potential as a cost-effective alternative for managing chronic wounds in resource-limited settings.
Authors
- Surasak Limsuwan (ORCID: https://orcid.org/0000-0002-4180-1416)
- Palika Wetchakul (ORCID: https://orcid.org/0000-0002-3824-9712)
- Sasitorn Chusri (ORCID: https://orcid.org/0000-0002-7365-6890)
- Pinanong Na-Phatthalung (ORCID: https://orcid.org/0000-0002-8162-4645)
- Acharaporn Issuriya (ORCID: https://orcid.org/0000-0002-8704-5695)
- Jian Tang (ORCID: https://orcid.org/0000-0003-3289-3352)
- Sineenart Sanpinit (ORCID: https://orcid.org/0000-0002-9688-3404)
- Oraphan Sakulkeo
- Siriwan Kantisin
Institutions
- Prince of Songkla University (TH)
- Mae Fah Luang University (TH)
- Bozhou People's Hospital (CN)
- Walailak University (TH)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-09
- DOI
- https://doi.org/10.3389/fphar.2025.1574715
- Citations
- 3
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.08
Funders
- Mae Fah Luang University
- Agricultural Research Development Agency