Assessing the Impact of Hypertension on Health-Related Quality of Life: Insights from Sociodemographic, Economic, and Clinical Features Using SF-36

<b>Background:</b> Hypertension significantly impacts the health-related quality of life (HRQoL) of patients. This study evaluates the influence of sociodemographic, economic, and clinical features on HRQoL among hypertensive patients using the 36-Item Short Form Survey (SF-36). <b>Method:</b> A cross-sectional study was conducted at a public health center in Khamis Mushayt, Saudi Arabia, where 209 adult hypertensive patients were surveyed using simple random sampling. Data were collected through a structured questionnaire covering sociodemographic and clinical details, and multiple linear regression was used to analyze the associations between variables and the SF-36 domains. Results: Of the 209 participants, 122 (58.4%) were female and 87 (41.6%) were male. Complications and multiple antihypertensive medications were linked to poorer physical functioning and general health (<i>p</i> < 0.05). Salt restriction improved physical functioning (B = 12.339, <i>p</i> = 0.008), and exercise reduced body pain (B = -8.487, <i>p</i> = 0.038). Middle-income patients had higher vitality (B = 7.632, <i>p</i> = 0.038) and social functioning (B = 16.465, <i>p</i> = 0.035). Higher-income individuals showed lower social functioning (B = -12.323, <i>p</i> = 0.022). <b>Conclusions:</b> Age, income, marital status, and complications were key determinants of HRQoL in hypertensive patients. Lifestyle interventions like exercise and salt restriction improve physical functioning and reduce pain, while psychological and social support are vital for mental health. Tailored interventions addressing clinical and psychosocial support are crucial for optimizing HRQoL in this population.