Effects of Aqueous Extract of Guava (Psidium guavaja linn) Leaves on Blood Glucose Level in Alloxan Induced Diabetic Rats

Background: Diabetes mellitus is an important cause of morbidity and mortality in many countries including Bangladesh. Herbal medicines have several advantages such as fewer side effects, less expensive and well accepted. Objectives: The study was done to evaluate the effects of aqueous extract of Psidium guajava linn leaves on blood glucose level of alloxan induced diabetic rats. Material and Methods: The experiment was carried out in the department of Pharmacology of Dhaka Medical College, Dhaka from July 2012 to June 2013. Thirty-two healthy Long Evan Norwegian strains of rats were equally divided into four groups (A, B, C and D). group A received standard rat food. Group B was given aqueous extract of Psidium guajava leaves 100mg/kg/day. Diabetes was introduced by administration of Alloxan 120mg/kg body weight in group C and D. Conclusion: The result showed that aqueous extract of Psiduim guajava leaves has no effects on blood glucose level in normal rats but can reduce blood glucose level in alloxan induced diabetic rats which needs further investigation.