Tauroursodeoxycholic Acid Induces Liver Regeneration and Alleviates Fibrosis Through GATA3 Activation
<b>Background</b>: Liver regeneration is a critical measure of liver health and plays an essential role in inhibiting the progression of fibrotic lesions and preventing liver failure after hepatocellular carcinoma surgery. However, there are no approved drugs to address this clinical challenge. <b>Methods</b>: The effects of TUDCA on liver regeneration and fibrosis were studied using BRL-3A cells, a partial hepatectomy (PH) rat liver regeneration model, and a carbon tetrachloride (CCl<sub>4</sub>)-induced liver fibrosis model. GATA3-knockdown BRL-3A cells were employed to assess the role of GATA3 in TUDCA-induced proliferation. <b>Results</b>: TUDCA promoted the proliferation of BRL-3A cells and enhanced liver regeneration in PH rats while ameliorating liver fibrosis in CCl<sub>4</sub>-treated rats. Additionally, the knockdown of GATA3 eliminated the proliferative effect of TUDCA on BRL-3A cells. <b>Conclusions</b>: TUDCA promotes liver regeneration and alleviates liver fibrosis by activating GATA3.
Authors
- Shaohua Yan (ORCID: https://orcid.org/0000-0002-3339-3184)
- Yuan Xie (ORCID: https://orcid.org/0000-0003-0569-1253)
- Jiatai Li (ORCID: https://orcid.org/0009-0004-8736-1892)
- Chunxue Bai (ORCID: https://orcid.org/0000-0001-5798-3130)
- Jiexi Yan
- Ruixi Chen (ORCID: https://orcid.org/0000-0002-3663-9768)
- Runfeng Li (ORCID: https://orcid.org/0000-0003-4153-0932)
- Jun Xu (ORCID: https://orcid.org/0000-0002-9255-0434)
- Lele Yang (ORCID: https://orcid.org/0000-0003-2573-4812)
- Yuting Zhang (ORCID: https://orcid.org/0000-0002-5467-2510)
- Yongqiang Zhou
- Xiaoyi Jin
- Qiuxia Zheng (ORCID: https://orcid.org/0000-0003-2415-7064)
- Fupeng Zhong
- Zongbin Sun
- Yi Shao (ORCID: https://orcid.org/0000-0002-5842-3167)
- Yue Zhang (ORCID: https://orcid.org/0000-0002-7786-0231)
- Xiaojing Song (ORCID: https://orcid.org/0009-0004-8458-5612)
Institutions
- Second Military Medical University (CN)
- Eastern Hepatobiliary Surgery Hospital (CN)
- First Hospital of Lanzhou University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Biomedicines
- Published
- 2025-04-09
- DOI
- https://doi.org/10.3390/biomedicines13040910
- Citations
- 3
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 3.97
Funders
- National Natural Science Foundation of China