UV-C and hydration state drive pulsed light-induced proteome damage in Bacillus pumilus spores
Although the overall inactivation rate could not be directly correlated with proteome damage, we identified that core proteins involved in DNA and RNA protection and repair were specifically targeted by PL. These findings provide new insights into the molecular mechanisms underlying PL-mediated microbial inactivation and highlight the role of protein photodamage in spore susceptibility.
Authors
- Catherine Duport (ORCID: https://orcid.org/0000-0003-3570-0288)
- Jean Armengaud (ORCID: https://orcid.org/0000-0003-1589-445X)
- Imed Dorbani
- Frédéric Carlin (ORCID: https://orcid.org/0000-0001-9230-7859)
Institutions
- Université d'Avignon et des Pays de Vaucluse (FR)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Paris-Saclay (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Laboratoire Informatique d'Avignon (FR)
- CEA Paris-Saclay (FR)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-04-09
- DOI
- https://doi.org/10.3389/fmicb.2025.1579161
- Citations
- 3
- Primary Topic
- Bacillus and Francisella bacterial research
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Association Nationale de la Recherche et de la Technologie
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement