The toxicity, uptake, and impact on galectin-3 mediated apoptosis of lactose functionalized PAMAM dendrimers
Four generations of lactose-functionalized PAMAM dendrimers show low toxicity, proclivity for uptake, and mediation of galectin-3 inhibition of apoptosis. Glycodendrimers are useful systems for studying galectin-3 in cancer cells.
Authors
- Elisa Quaas
- Mackenzie S. Fricke
- Rainer Haag (ORCID: https://orcid.org/0000-0003-3840-162X)
- Katharina Achazi (ORCID: https://orcid.org/0000-0003-2189-291X)
- Raiha Tahir
- Mary J. Cloninger (ORCID: https://orcid.org/0000-0002-7551-1003)
- Samuel P. Bernhard (ORCID: https://orcid.org/0000-0001-9561-9508)
- Yannic Kerkhoff (ORCID: https://orcid.org/0000-0002-8126-2082)
- Magalee R. Frometa
- William H. Totten
Institutions
- Zuse Institute Berlin (DE)
- Montana State University (US)
- Freie Universität Berlin (DE)
Publication Details
- Journal
- Materials Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d4ma00782d
- Primary Topic
- Galectins and Cancer Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- U.S. Department of Defense
- M.J. Murdock Charitable Trust
- Montana State University
- Deutsche Forschungsgemeinschaft
- Defense Human Resources Activity
- Division of Electrical, Communications and Cyber Systems
- Division of Chemistry