Disturbing Cholesterol/Sphingolipid Metabolism by Squalene Epoxidase Arises Crizotinib Hepatotoxicity (Adv. Sci. 14/2025)
Crizotinib HepatotoxiCityIn article number 2414923, Peihua Luo, Hao Yan, Xiangliang Huang, and co-workers report the mechanism of crizotinib hepatotoxicity, wherein crizotinib disturbs normal lipid metabolism through accumulation of squalene epoxidase (SQLE).The liver damage caused by crizotinib is similar to persistent sunshine exposure, which causes desertification changes in the "liver land," whereas rainfall (representing metformin and terbinafine) can prevent such alterations.
Authors
- Hao Yan (ORCID: https://orcid.org/0000-0003-0578-7212)
- Xiangliang Huang
- Bo Yang (ORCID: https://orcid.org/0000-0002-6505-2771)
- Zhifei Xu (ORCID: https://orcid.org/0000-0002-1896-097X)
- Wentong Wu
- Shaoyin Zhang
- Peihua Luo (ORCID: https://orcid.org/0000-0002-6576-2052)
- Xiaochen Zhang (ORCID: https://orcid.org/0000-0002-1766-9953)
- Xueqin Chen (ORCID: https://orcid.org/0000-0002-1828-1985)
- Mu Yuan (ORCID: https://orcid.org/0009-0008-6515-3100)
- Qiaojun He (ORCID: https://orcid.org/0000-0002-0104-6989)
- Yourong Zhou (ORCID: https://orcid.org/0009-0005-5787-7799)
- Xiaochun Yang (ORCID: https://orcid.org/0000-0002-2248-5235)
- Yashi Cao
- Xiaohong Wang
Publication Details
- Journal
- Advanced Science
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/advs.202570098
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00